PD0325901 is a small molecule targeting mitogen-activated protein kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation^1,2. Along with the ALK5 inhibitor SB431542, PD0325901 has also been shown to increase the efficiency of reprogramming human primary fibroblasts into induced pluripotent stem (iPS) cells³.

Also available as a 10 mM stock solution in DMSO(Cat. No. 04-0006-02)

Stemgent conveniently provides all the components comprising the 5i/L/A media supplement necessary to support naive pluripotent stem cell applications.

5i(inhibitors):

• Stemolecule PD0325901(04-0006),
• Stemolecule Y27632(04-0012),
• Stemolecule WH-4-023(04-0079),
• Stemolecule SB590885(04-0080),
• Stemolecule IM-12(04-0081) or alternatively,Stemolecule CHIR99021(04-0004)

L:Stemfactor LIF, Human Recombinant(03-0016), and

A:Stemfactor Activin A, Human Recombinant(03-0001)